Von Recklinghausen neurofibromatosis: a linkage study of candidate and random marker genes.
نویسندگان
چکیده
Genotyping, using plasma proteins or DNA polymorphisms or both, was carried out on 30 families selected through probands with Von Recklinghausen disease. The data provide additional evidence for the exclusion of loci on chromosomes 3 and 5, and chromosome arms 1q, 2p, 4p, 4q, 6q, 7p, 9q, 11p, 11q, and 14q. There was no evidence for genetic heterogeneity at D1S1 (DNF15S2) on chromosome arm 3p, using the Morton test for heterogeneity.
منابع مشابه
Linkage analysis of British and Indian families with Von Recklinghausen neurofibromatosis.
Linkage analysis has been undertaken in two British and three South African Indian families with Von Recklinghausen neurofibromatosis. Eleven polymorphic DNA probes were studied, including both random DNA sequences and candidate oncogenes. Although no evidence for linkage of these probes to the disease was detected, substantial exclusion regions were established on six of the chromosomes studied.
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ورودعنوان ژورنال:
- Journal of medical genetics
دوره 24 9 شماره
صفحات -
تاریخ انتشار 1987